Direct evidence for the contribution of the unique I-ANOD to the development of insulitis in non-obese diabetic mice

作者: Toru Miyazaki , Masashi Uno , Masahiro Uehira , Hitoshi Kikutani , Tadamitsu Kishimoto

DOI: 10.1038/345722A0

关键词:

摘要: … diabetes prevented in NOD/Lt mice expressing IA". To determine whether the unique I–A molecule of the diabetes-prone NOD/Lt mouse … into NOD/Lt mice using transgenic technology. I–…

参考文章(25)
Susumu MAKINO, Kikuko KUNIMOTO, Yoshihiro MURAOKA, Yukio MIZUSHIMA, Ken KATAGIRI, Yoshihiro TOCHINO, Breeding of a non-obese, diabetic strain of mice. Jikken dobutsu. Experimental animals. ,vol. 29, pp. 1- 13 ,(1980) , 10.1538/EXPANIM1978.29.1_1
P. A. Morel, J. S. Dorman, J. A. Todd, H. O. McDevitt, M. Trucco, Aspartic acid at position 57 of the HLA-DQ beta chain protects against type I diabetes: a family study. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 85, pp. 8111- 8115 ,(1988) , 10.1073/PNAS.85.21.8111
M Hattori, JB Buse, RA Jackson, L Glimcher, ME Dorf, M Minami, S Makino, K Moriwaki, H Kuzuya, H e at Imura, WM Strauss, JG Seidman, GS Eisenbarth, The NOD mouse: recessive diabetogenic gene in the major histocompatibility complex Science. ,vol. 231, pp. 733- 735 ,(1986) , 10.1126/SCIENCE.3003909
Louis A. Matis, Simona B. Sorger, David L. McElligott, Pamela J. Fink, Stephen M. Hedrick, The molecular basis of alloreactivity in antigen-specific, major histocompatibility complex-restricted T cell clones Cell. ,vol. 51, pp. 59- 69 ,(1987) , 10.1016/0092-8674(87)90010-9
N. S. Braunstein, R. N. Germain, Allele-specific control of Ia molecule surface expression and conformation: implications for a general model of Ia structure-function relationships Proceedings of the National Academy of Sciences of the United States of America. ,vol. 84, pp. 2921- 2925 ,(1987) , 10.1073/PNAS.84.9.2921
J. Todd, H Acha-Orbea, J. Bell, N Chao, Z Fronek, C. Jacob, M McDermott, A. Sinha, L Timmerman, L Steinman, al. et, A molecular basis for MHC class II--associated autoimmunity Science. ,vol. 240, pp. 1003- 1009 ,(1988) , 10.1126/SCIENCE.3368786
Bernard Malissen, Michael Steinmetz, Minnie McMillan, Michel Pierres, Leroy Hood, Expression of I-Ak class II genes in mouse L cells after DNA-mediated gene transfer. Nature. ,vol. 305, pp. 440- 443 ,(1983) , 10.1038/305440A0
M WATANABE, N SHINOHARA, A OCHI, N HOZUMI, Functional reconstitution of class II major histocompatibility complex molecules, I-Aαk and I-Aβk Immunology Letters. ,vol. 13, pp. 237- 244 ,(1986) , 10.1016/0165-2478(86)90108-2
Hirofumi Nishimoto, Hitoshi Kikutani, Ken-ichi Yamamura, Tadamitsu Kishimoto, Prevention of autoimmune insulitis by expression of I-E molecules in NOD mice Nature. ,vol. 328, pp. 432- 434 ,(1987) , 10.1038/328432A0
Eva-Pia Reich, Robert S. Sherwin, Osami Kanagawa, Charles A. Janeway, An explanation for the protective effect of the MHC class II I-E molecule in murine diabetes. Nature. ,vol. 341, pp. 326- 328 ,(1989) , 10.1038/341326A0