Microbial transformations of natural antitumor agents. IV. Formation of N-(2)-nor-d-tetrandrine by Cunninghamella blakesleeana (ATCC 8688a).

摘要: Microbial transformation experiments have been conducted with the antitumor alkaloid, d-tetrandrine. The alkaloid is selectively demethylated at N-(2)-position by Cunninghamella blakesleeana ATCC 8688a. biotransformation reaction highly selective and uncomplicated side-product formation. N-demethylation of using methylchloroformate not regio-specific. Procedures used in screening microorganisms for their abilities to yield metabolites d-tetrandrine are evaluated.