Neurologic complications after liver transplantation

摘要: Neurologic complications are relatively common after solid organ transplantation and affect 15%-30% of liver transplant recipients. Etiology is often related to immunosuppressant neurotoxicity opportunistic infections. Most include seizures encephalopathy, occurrence central pontine myelinolysis specific for Delayed allograft function may precipitate hepatic encephalopathy calcineurin inhibitors typically manifests with tremor, headaches encephalopathy. Reduction neurotoxic immunosuppressants or conversion an alternative medication usually result in clinical improvement. Standard preventive diagnostic protocols have helped reduce the prevalence nervous system (CNS) infections, but viral fungal CNS infections still 1% recipients, morbidity mortality affected patients remain fairly high. Critical illness myopathy also up 7% Liver insufficiency associated various neurologic disorders which improve resolve successful transplantation. Accurate diagnosis timely intervention essential outcomes, while advances management extended post-transplant survival increasingly shifting focus chronic encountered a community hospital outpatient setting.