Regional and cellular codistribution of interleukin 1 beta and nerve growth factor mRNA in the adult rat brain: possible relationship to the regulation of nerve growth factor synthesis.
作者： C E Bandtlow , M Meyer , D Lindholm , M Spranger , R Heumann
关键词:
摘要: We have found a regional distribution of IL 1 beta mRNA and activity in the normal adult rat brain, which reveals at least partially colocalization with nerve growth factor (NGF). The predominantly neuronal signal patterns were over granule cells dentate gyrus, pyramidal hippocampus, cerebellum, periglomerular olfactory bulb, dispersed ventromedial hypothalamus frontal cortex. In these areas also highest levels observed. striatum septum much lower (shown for striatum), most likely synthesized by glial cells, could be determined. beta-expressing mainly brain regions that synthesize NGF as shown situ hybridization. demonstrated bulb prefrontal cortex neurons. These data indicate beta, among other factors, might play regulatory role synthesis CNS, has been peripheral nervous system (Lindholm, D., R. Heumann, M. Meyer, H. Thoenen. 1987. Nature (Lond.). 330:658-659).
core.ac.uk
rupress.org
jcb.org参考文章(37)
S. Korsching, G. Auburger, R. Heumann, J. Scott, H. Thoenen, Levels of nerve growth factor and its mRNA in the central nervous system of the rat correlate with cholinergic innervation. The EMBO Journal. ,vol. 4, pp. 1389- 1393 ,(1985) , 10.1002/J.1460-2075.1985.TB03791.X
Hans Thoenen, Christine Bandtlow, Rolf Heumann, The physiological function of nerve growth factor in the central nervous system: comparison with the periphery. Reviews of Physiology Biochemistry and Pharmacology. ,vol. 109, pp. 145- 178 ,(1987) , 10.1007/BFB0031026
D Lindholm, R Heumann, B Hengerer, H Thoenen, Interleukin 1 increases stability and transcription of mRNA encoding nerve growth factor in cultured rat fibroblasts. Journal of Biological Chemistry. ,vol. 263, pp. 16348- 16351 ,(1988) , 10.1016/S0021-9258(18)37599-9
D Pennica, D V Goeddel, P W Gray, D Glaister, E Chen, Two interleukin 1 genes in the mouse: cloning and expression of the cDNA for murine interleukin 1 beta. Journal of Immunology. ,vol. 137, pp. 3644- 3648 ,(1986)
D J Hazuda, J C Lee, P R Young, The kinetics of interleukin 1 secretion from activated monocytes. Differences between interleukin 1 alpha and interleukin 1 beta. Journal of Biological Chemistry. ,vol. 263, pp. 8473- 8479 ,(1988) , 10.1016/S0021-9258(18)68502-3
R. Heumann, D. Lindholm, C. Bandtlow, M. Meyer, M. J. Radeke, T. P. Misko, E. Shooter, H. Thoenen, Differential regulation of mRNA encoding nerve growth factor and its receptor in rat sciatic nerve during development, degeneration, and regeneration: role of macrophages. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 84, pp. 8735- 8739 ,(1987) , 10.1073/PNAS.84.23.8735
M. Nieto-Sampedro, M. A. Berman, Interleukin-1-like activity in rat brain: sources, targets, and effect of injury. Journal of Neuroscience Research. ,vol. 17, pp. 214- 219 ,(1987) , 10.1002/JNR.490170303
Paul D. Rennert, Gerhard Heinrich, Nerve growth factor mRNA in brain: Localization by in situ hybridization Biochemical and Biophysical Research Communications. ,vol. 138, pp. 813- 818 ,(1986) , 10.1016/S0006-291X(86)80569-1
Matthias Spranger, Dan Lindholm, Christine Bandtlow, Rolf Heumann, Hannes Gnahn, Martina Naher-Noe, Hans Thoenen, Regulation of Nerve Growth Factor (NGF) Synthesis in the Rat Central Nervous System: Comparison between the Effects of Interleukin-1 and Various Growth Factors in Astrocyte Cultures and in vivo. European Journal of Neuroscience. ,vol. 2, pp. 69- 76 ,(1990) , 10.1111/J.1460-9568.1990.TB00382.X
Dan Lindholm, Rolf Heumann, Michael Meyer, Hans Thoenen, Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve. Nature. ,vol. 330, pp. 658- 659 ,(1987) , 10.1038/330658A0