Acquisition of response thresholds for timed performance is regulated by a calcium-responsive transcription factor, CaRF.

摘要: Interval timing within the seconds-to-minutes range involves interaction of prefrontal cortex and basal ganglia via dopaminergic–glutamatergic pathways. Because secreted protein brain-derived neurotrophic factor (BDNF) is able to modulate dopamine release as well glutamatergic activity, we hypothesized that BDNF may be important for these mechanisms. Recently, calcium-responsive transcription (CaRF) was identified an modulator expression in cerebral cortex. In this study, a strain Carf knockout mice evaluated their ability acquire ‘Start’ ‘Stop’ response thresholds under sequential simultaneous training conditions, using multiple (15-second 45-second) or single (30-second) target durations peak-interval procedure. Both Carf+/− Carf−/− were impaired timed relative Carf+/+ mice. Additionally, control given microinjections antisense oligodeoxynucleotide inhibit showed impairments during acquisition similar Together, results suggest inhibitory processes required update exert temporal behavior dependent on CaRF regulation genes including Bdnf cortico-striatal circuits.