MP37-19 AXIN2 EXPRESSION PREDICTS PROSTATE CANCER RECURRENCE AND MEDIATES AN INVASIVE, TUMORIGENIC PHENOTYPE

摘要: INTRODUCTION AND OBJECTIVES: Better biomarkers are needed in prostate cancer (PCa) to predict disease recurrence and guide optimal therapy. We investigated whether genes associated with a highly tumorigenic, drug resistant, progenitor phenotype impact PCa biology clinical outcomes localized disease. METHODS: Radical prostatectomy (RP) specimens (þ/disease recurrence) were analyzed by qRT-PCR quantify expression of self-renewal, resistance, tumorigenicity prior studies. Univariable multivariable associations between gene confirmed bootstrap internal validation external independent cohorts in-silico. siRNA knockdown lentiviral overexpression used determine the effect on proliferation, invasion tumor growth. RESULTS: Four candidate differentially expressed recurrence, these, low AXIN2 was internally validated. In silico, independently more aggressive PCa, biochemical metastasis-free survival after RP. vitro vivo, stem-like cell-surface signature, resulted significantly greater invasiveness. Conversely, ectopic reduced cell proliferation growth mice (Figure). CONCLUSIONS: Low RP our test population as well cohorts, its levels cells impacted invasiveness, Based these novel roles may represent new putative biomarker potential therapeutic target this