Chemical Characterization and Cytotoxic Activity of Antarctic Macroalgae Extracts against Colorectal Cancer

摘要: Background/Aim: Antarctic seaweeds are considered a promising source of compounds with anticancer activity. Colorectal cancer (CRC) is one the most incident cancers with high mortality rates worldwide. This work aimed to characterize chemically extracts Antarctic macroalgae Iridaea cordata, Cystosphaera jacquinotii and Desmarestia anceps evaluate cytotoxic effects against human colon HCT 116 cell line. Materials Methods: The were obtained by depletion using an ultrasound probe identified High-Performance Liquid Chromatography (HPLC) Gas Chromatography coupled Mass Spectrometry (GC-MS). Cell viability was determined MTT assay. Results: Hexanic chloroform I. cordata hexanic, chloroform methanolic D. able inhibit growth of colorectal cells in three different incubation times (24, 48 72 h). Through GC analysis, 01 hexane extract 02 compounds algae cordata. The presented 5 compounds, 10 3 respectively, special highlight fucosterol. Carotenoid analysis HPLC β-carotene in all species, while zeaxanthin present spectrum C. jacquinotii. Fucoxanthin violaxanthin confirmed the brown anceps. Conclusion: Extracts Cordata may be source of therapeutic agents CRC.