Honey for acute cough in children.

摘要: Background Cough causes concern for parents and is a major cause of outpatient visits. It can impact on quality life, anxiety affect sleep in children. Several remedies, including honey, have been used to alleviate cough symptoms. Objectives To evaluate the effectiveness honey acute children ambulatory settings. Search methods We searched CENTRAL (2014, Issue 10), MEDLINE (1950 October week 4, 2014), EMBASE (1990 November CINAHL (1981 Web Science (2000 AMED (1985 LILACS (1982 2014) CAB abstracts (2009 January 2014). Selection criteria Randomised controlled trials (RCTs) comparing given alone, or combination with antibiotics, versus nothing, placebo other over-the-counter (OTC) medications participants aged from one 18 years settings. Data collection analysis Two review authors independently screened search results eligible studies extracted data reported outcomes. Main results We included three RCTs, two at high risk bias low bias, involving 568 The compared dextromethorphan, diphenhydramine, 'no treatment' effect symptomatic relief using seven-point Likert scale. lower score, better symptom being assessed. Moderate evidence showed that may be than reducing frequency (mean difference (MD) -1.05; 95% confidence interval (CI) -1.48 -0.62; I2 statistic 23%; studies, 154 participants). High also suggests reduction (MD -1.85; Cl -3.36 -0.33; study, 300 Moderate does not differ significantly dextromethorphan -0.07; CI -1.07 0.94; 149 Low slightly diphenhydramine -0.57; -0.90 -0.24; 80 participants). Adverse events mild reactions (nervousness, insomnia hyperactivity) experienced by seven (9.3%) group (2.7%) group; was significant (risk ratio (RR) 2.94; 0.74 11.71; Three (7.5%) somnolence (RR 0.14; 0.01 2.68; When placebo, four (1.8%) (1.3%) complained gastrointestinal symptoms 1.33; 0.15 11.74). However, there no between placebo. No adverse event group. Authors' conclusions Honey treatment', cough, but it dextromethorphan. None assessed 'cough duration' because intervention follow-up were night only. There strong against use honey.