The effect of colloid formulation on colloid osmotic pressure in horses with naturally occurring gastrointestinal disease

摘要: Naturally occurring gastrointestinal disease is an important cause of acute hypoproteinemia in adult horses and hydroxyethyl starch colloid fluid treatment a component supportive care these cases to improve plasma volume maintain osmotic pressure (COP). The objectives the present study were compare 2 formulations high molecular weight their relative effect on COP, acid-base status, survival with secondary disease. Twenty horses, ≥ 1 year age, prospectively enrolled, informed client consent, if they developed hypoproteinemia, defined as total protein <5.0 g/dL or albumin <2.2 during hospitalization while undergoing for Horses randomly assigned receive rapid infusion either 6% 0.9% saline lactated ringers solution at dose 10ml/kg. Venous blood gas analysis, PCV evaluated before after administration. For both groups, average COP prior was 11.0 mmHg (9.7 – 12.2 mmHg) post 13.2 (12.0 -14.7 [Normal range 18 22 mmHg]. significantly increased (p<0.001) but this increase not different between groups. pH did change treatment. Twelve survived hospital discharge differ Post-treatment improved approximately 20% regardless formulation used, however, values reach normal observed healthy horses. Acid-base parameters impacted by Further needed determine how two products regards other outcome measures. Evaluation effects clinical future area interest.