Application of Antibody Engineering in the Development of Next Generation Antibody-Based Therapeutics

摘要: The evolution of therapeutic antibodies has encompassed multiple engineering efforts in the hope improving efficacy, safety, and duration effects antibody-based drugs. Advances protein technologies afforded investigators ability to overcome problems associated with introducing foreign into humans. These included antibody chimerization, humanization, more recent development human antibodies, all which reduced anti-drug immune responses. Additional have engineered variable regions that encode specificities a single molecular entity. Apart from optimizing antigen-binding capabilities reducing immunogenicity, many advances been made modulate an antibody’s interact cells serum components system. Manipulation glycosylation or amino acid sequence had significant impact on recruitment Fc-dependent effector functions. This chapter presents overview V region Fc modifications focuses tailor function relative intended need.