Pathogenic role of P-selectin in experimental cerebral malaria: importance of the endothelial compartment.

摘要: P-selectin is a leukocyte adhesion receptor expressed on the surface of activated platelets and endothelial cells. Its role in pathogenesis cerebral malaria was explored murine model malaria. Infection mice with Plasmodium berghei ANKA led to up-regulation brain vessels malaria-susceptible but not malaria-resistant mice. Treatment susceptible anti-mouse mAb failed prevent development neurological syndrome. However, P-selectin-deficient infected had cumulative incidence which significantly reduced compared wild-type animals (4.5% versus 80%, respectively), despite identical levels parasitemia, platelet accumulation. To determine whether and/or endothelium responsible for microvascular pathology, assessed chimeric deficient or P-selectin, were generated by bone marrow transplantation. Mice only did show any sign (vascular plugging, hemorrhages, edema), while lacking showed signs similar that seen These results indicate plays an important