The APOE ɛ4 allele affects complexity and functional connectivity of resting brain activity in healthy adults.
作者： Albert C. Yang , Chu-Chung Huang , Mu-En Liu , Yin-Jay Liou , Chen-Jee Hong
DOI: 10.1002/HBM.22398
关键词:
摘要: The apolipoprotein E (APOE) gene is associated with structural and functional brain changes. We have used multiscale entropy (MSE) analysis to detect changes in the complexity of resting blood oxygen level-dependent (BOLD) signals aging cognitive function. In this study, we further hypothesized that APOE genotype may affect spontaneous BOLD activity younger older adults, such altered be certain connectivity. conducted a resting-state magnetic resonance imaging experiment cohort 100 adults (aged 20–39 years; mean 27.2 ± 4.3 male/female: 53/47) 112 60–79 68.4 ± 6.5 54/58), applied voxelwise MSE assess main effect on Although was not observed group, ɛ4 allele carriers had significant reductions precuneus posterior cingulate regions, relative noncarriers. also reduced regions increased connectivity superior inferior frontal gyrus group. These results support compensatory recruitment hypothesis carriers, confer impact temporal dynamics adults. Hum Brain Mapp 35:3238–3248, 2014. © 2013 Wiley Periodicals, Inc.
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