How Imaging Can Impact Clinical Trial Design

摘要: The ability to measure biochemical and molecular processes guide cancer treatment represents a potentially powerful tool for trials of targeted therapy. These assays have traditionally been performed by analysis tissue samples. However, more recently, functional imaging has developed that is capable in vivo biochemistry biology highly complementary tissue-based assays. Cancer biomarkers can play key role increasing the efficacy efficiency therapeutic clinical also provide insight into biologic mechanisms bring about response. Future progress will depend on close collaboration between scientists physicians public commercial sponsors, take full advantage what offer This review examples how inform decision making (1) measuring regional expression target, (2) assessing early (pharmacodynamic) response treatment, (3) predicting outcome. includes discussion basic principles cancer, with an emphasis those methods tested patients. We then designed evaluate tests as integrated markers embedded trial goal validating integral aid patient selection direct response-adapted strategies. Examples recently completed multicenter using are highlighted.