Taxol-induced sensory disturbance is characterized by preferential impairment of myelinated fiber function in cancer patients.

摘要: Taxol produces neuropathic pain with three distinct zones of involvement in the extremities. Most distally is an area on-going and proximal to this a zone sensory disturbance but not overt pain. These two areas were confined all one case glabrous skin hands and/or feet. More recognized by patients as involved or yet wherein quantitative tests nevertheless reveal altered sensibility. Impairment perception light touch, normally conveyed myelinated fibers, was dramatically areas, being approximately 50-fold greater than normal well perceived affected. sharpness, small most pronounced pain, intermediate near baseline more chemotherapy patients. In contrast mechanical sensibility, thermal thresholds for warm heat detection throughout. Finally, showed paradoxical burning cooling that thought be unaffected patients, border sensibility least data suggest taxol neuropathy characterized impairment function A-beta A-delta relative sparing C-fibers.