The self-association of acebutolol: Conductometry and light scattering

摘要: The association characteristics of an amphiphilic beta-blocker drug, acebutolol hydrochloride, in aqueous solution containing high concentrations electrolyte and at different temperatures have been examined by static dynamic light scattering electrical conductivity. Time averaged measurements on solutions 298.15 K the presence added (0.4–1.0 mol kg−1 NaCl) shown discontinuities which reflect appearance aggregates. critical micelle concentration, aggregation numbers, effective charges, degree micellar ionization were calculated. Dynamic has increase size with concentration electrolyte. Data interpreted using DLVO theory to quantify interaction between drug aggregates colloidal stability. Critical water calculated from conductivity over temperature range 288.15–313.15...