Meningeal Carcinomatosis: Development of an Experimental Model

摘要: An experimental model of meningeal carcinomatosis has been produced by intracisternal inoculation Walker 256 carcinoma cell suspension into Wistar rats. The tumor grows rapidly and is fatal in about 15 days if 10(6) cells are injected. histopathological pattern observed similar to that seen diffuse leptomeningeal involvement systemic cancer human beings. will be useful for investigating the pathophysiology neurological disability efficacy chemotherapeutic agents.