Genetic evidence for a role for protein kinase A in the maintenance of sleep and thalamocortical oscillations.
作者： Kevin Hellman , Pepe Hernandez , Alice Park , Ted Abel
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摘要: Study Objectives: Genetic manipulation of cAMP-dependent protein kinase A (PKA) in Drosophila has implicated an important role for PKA sleep/wake state regulation. Here, we characterize the this signaling pathway regulation sleep using electroencephalographic (EEG) and electromyographic (EMG) recordings R(AB) transgenic mice that express a dominant negative form regulatory subunit neurons within cortex hippocampus. Previous studies have revealed these mutant reduced activity results impairment hippocampus-dependent long-term memory long-lasting forms hippocampal synaptic plasticity.
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