Extended release formulation of diltiazem hydrochloride

摘要: An extended release formulation of diltiazem which is suitable for once-daily oral administration comprises a quantity quick preparation or pharmaceutically active salt thereof, mixed with slow (or delayed release) thereof. The used obtains maximal within approximately 1-2 hours after administration, and then falls toward baseline levels. individually shows at between 6-8 administration. containing the two achieves levels released remain near these another 12 compared to other formulations (referred herein as preparations) achieve 9 preferred embodiment capsule formulation, which, based upon total drug in rather than weight up 25 percent by diltiazem, 75 delayed) diltiazem. present invention has application combinations preparations pharmaceuticals.