Survival in overweight patients with advanced pancreatic carcinoma: a multicentre cohort study

摘要: Obesity is a risk factor for developing pancreatic cancer. We investigated the impact of obesity on survival in patients diagnosed with locally advanced or metastatic In multicentre, retrospective study, we included all cancer treated at four Swiss hospitals between 1994 and 2004. categorized into body mass index (BMI) groups (<18.5, 18.5 – 25, ≥ 25 29, ≥30 kg/m2) used multivariable Cox regression to investigate BMI survival. Missing data were handled using multiple imputations. 483 included. Median age was 66 years (range 59–74), 47% female, 82% had stage IV disease, 72% an ECOG below 2, 84% gemcitabine-based first-line chemotherapy. After median follow-up 8.5 months, 6 12-month probabilities whole cohort 67% (95% CI 63% - 71%) 37% 33% 42%), respectively. Unadjusted rates each group were: 48% 62%), 42% 36% 48%), 30% 22% 38%), 11% 4% 24%), analysis, increasing (HR 1.22, 95% 1.04 1.41, p = 0.012) CA 19–9 1.07, 1.02 1.11, p = 0.003) significantly associated worse prognosis. Patients good clinical performance status (ECOG < 2) better prognosis 0.76, 0.65 0.96, p = 0.019). Obese cancers have compared non-obese patients. should be considered stratification future trials.