Recent Developments in New Therapeutic Agents against Alzheimer and Parkinson Diseases: In-Silico Approaches.

摘要: Neurodegenerative diseases (ND), including Alzheimer's (AD) and Parkinson's Disease (PD), are becoming increasingly more common recognized as a social problem in modern societies. These disorders characterized by progressive neurodegeneration considered one of the main causes disability mortality worldwide. Currently, there is no existing cure for AD nor PD clinically used drugs aim only at symptomatic relief, not capable stopping neurodegeneration. Over last years, several drug candidates reached clinical trials phases, but they were suspended, mainly because unsatisfactory pharmacological benefits. Recently, number compounds developed using silico approaches has been increasing promising rate, evaluating affinity macromolecular targets applying filters to exclude with potentially unfavorable pharmacokinetics. Thus, this review, an overview current therapeutics use these two ND, development, primary studies published five years that design novel treatment will be presented. In addition, future perspectives ND also briefly discussed.