Programmed Necrosis: A “New” Cell Death Outcome for Injured Adult Neurons?

摘要: Historically, cell death has been divided into two generic categories: apoptosis, which requires energy and in the plays an active role, necrosis, occurs accidentally, does not require consumption is considered as a passive, uncontrolled program. Among conceptually opposite forms, apoptosis best understood. This program defined developmentally programmed ordered cellular response. Apoptosis initiated by rounding subsequent detachment from surrounding cells. Chromatin condenses “crescent-like” forms abutting inner nuclear membrane. Plasma membrane convolutes gives rise to characteristic vesicles containing organelles cytoplasm, known “apoptotic bodies.” generally accompanied inflammation since macrophages or neighbouring cells engulf formed apoptotic bodies before loss of plasma integrity (Kerr et al. 1972). In contrast necrosis characterized disruption with water influx leakage content surroundings. Cell can elicit inflammatory response (Edinger Thompson 2004).