Exploring HIV-1 Transmission Dynamics by Combining Phylogenetic Analysis and Infection Timing.

摘要: HIV-1 pol sequences obtained through baseline drug resistance testing of patients newly diagnosed between 2013 and 2017 were analyzed for genetic similarity. For 927 the information on similarity was combined with demographic data recency infection. Overall, 48.3% genetically linked 11.4% belonging to a pair 36.9% involved in cluster ≥3 members. The percentage early (≤4 months after infection) 28.6%. Patients Belgian origin more frequently transmission clusters (49.7% compared 15.3%) earlier (37.4% 12.2%) than Sub-Saharan African origin. Of infections reported be locally acquired, 69.5% (14.1% paired 55.4% cluster). Equal parts late individuals (59.9% 52.4%, respectively) clusters. identification individual majority infected suggests high rate diagnosis this population. Diagnosis however is often delayed >4 infection increasing opportunities onward transmission. Prevention local should focus protection still uninfected members sexual networks human immunodeficiency virus (HIV)-infected