Timing of meals: when is as critical as what and how much

摘要: Over the past decade, a large body of literature has demonstrated that disruptions endogenous circadian clock, whether environmental or genetic, lead to metabolic dysfunctions are associated with obesity, diabetes, and other disorders. The phrase, “It is not only what you eat how much eat, but also when eat” sends simple message about timing weight regulation. Communicating this clinicians patients, while elucidating neuroendocrine, molecular, genetic mechanisms underlying phrase essential embrace growing knowledge impact on metabolism as part healthy life style well incorporate it into clinical practice for improvement overall human health. In review, we discuss findings from animal models, epidemiological studies in humans, which collectively promote awareness role clock functions dysfunctions.