An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells
作者： D. Rohle , J. Popovici-Muller , N. Palaskas , S. Turcan , C. Grommes
关键词:
摘要: … ) that impairs the growth of R132H-IDH1-mutant, but not IDH1 wild-type, glioma cells. This data demonstrates an important role of mutant IDH1 in tumor maintenance, in addition to its …
sciencemag.org
harvard.edu参考文章(27)
Dengke K Ma, Maria Carolina Marchetto, Junjie U Guo, Guo-li Ming, Fred H Gage, Hongjun Song, None, Epigenetic choreographers of neurogenesis in the adult mammalian brain Nature Neuroscience. ,vol. 13, pp. 1338- 1344 ,(2010) , 10.1038/NN.2672
Sevin Turcan, Daniel Rohle, Anuj Goenka, Logan A. Walsh, Fang Fang, Emrullah Yilmaz, Carl Campos, Armida W. M. Fabius, Chao Lu, Patrick S. Ward, Craig B. Thompson, Andrew Kaufman, Olga Guryanova, Ross Levine, Adriana Heguy, Agnes Viale, Luc G. T. Morris, Jason T. Huse, Ingo K. Mellinghoff, Timothy A. Chan, IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype Nature. ,vol. 483, pp. 479- 483 ,(2012) , 10.1038/NATURE10866
M Fernanda Amary, Krisztian Bacsi, Francesca Maggiani, Stephen Damato, Dina Halai, Fitim Berisha, Robin Pollock, Paul O'Donnell, Anita Grigoriadis, Tim Diss, Malihe Eskandarpour, Nadège Presneau, Pancras CW Hogendoorn, Andrew Futreal, Roberto Tirabosco, Adrienne M Flanagan, IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours The Journal of Pathology. ,vol. 224, pp. 334- 343 ,(2011) , 10.1002/PATH.2913
Rasheduzzaman Chowdhury, Kar Kheng Yeoh, Ya‐Min Tian, Lars Hillringhaus, Eleanor A Bagg, Nathan R Rose, Ivanhoe K H Leung, Xuan S Li, Esther C Y Woon, Ming Yang, Michael A McDonough, Oliver N King, Ian J Clifton, Robert J Klose, Timothy D W Claridge, Peter J Ratcliffe, Christopher J Schofield, Akane Kawamura, The oncometabolite 2‐hydroxyglutarate inhibits histone lysine demethylases EMBO Reports. ,vol. 12, pp. 463- 469 ,(2011) , 10.1038/EMBOR.2011.43
Masato Sasaki, Christiane B. Knobbe, Joshua C. Munger, Evan F. Lind, Dirk Brenner, Anne Brüstle, Isaac S. Harris, Roxanne Holmes, Andrew Wakeham, Jillian Haight, Annick You-Ten, Wanda Y. Li, Stefanie Schalm, Shinsan M. Su, Carl Virtanen, Guido Reifenberger, Pamela S. Ohashi, Dwayne L. Barber, Maria E. Figueroa, Ari Melnick, Juan-Carlos Zúñiga-Pflücker, Tak W. Mak, IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics Nature. ,vol. 488, pp. 656- 659 ,(2012) , 10.1038/NATURE11323
D. W. Parsons, S. Jones, X. Zhang, J. C.-H. Lin, R. J. Leary, P. Angenendt, P. Mankoo, H. Carter, I-M. Siu, G. L. Gallia, A. Olivi, R. McLendon, B. A. Rasheed, S. Keir, T. Nikolskaya, Y. Nikolsky, D. A. Busam, H. Tekleab, L. A. Diaz, J. Hartigan, D. R. Smith, R. L. Strausberg, S. K. N. Marie, S. M. O. Shinjo, H. Yan, G. J. Riggins, D. D. Bigner, R. Karchin, N. Papadopoulos, G. Parmigiani, B. Vogelstein, V. E. Velculescu, K. W. Kinzler, An Integrated Genomic Analysis of Human Glioblastoma Multiforme Science. ,vol. 321, pp. 1807- 1812 ,(2008) , 10.1126/SCIENCE.1164382
Michael A McDonough, Christoph Loenarz, Rasheduzzaman Chowdhury, Ian J Clifton, Christopher J Schofield, Structural studies on human 2-oxoglutarate dependent oxygenases Current Opinion in Structural Biology. ,vol. 20, pp. 659- 672 ,(2010) , 10.1016/J.SBI.2010.08.006
Maria E. Figueroa, Omar Abdel-Wahab, Chao Lu, Patrick S. Ward, Jay Patel, Alan Shih, Yushan Li, Neha Bhagwat, Aparna Vasanthakumar, Hugo F. Fernandez, Martin S. Tallman, Zhuoxin Sun, Kristy Wolniak, Justine K. Peeters, Wei Liu, Sung E. Choe, Valeria R. Fantin, Elisabeth Paietta, Bob Löwenberg, Jonathan D. Licht, Lucy A. Godley, Ruud Delwel, Peter J.M. Valk, Craig B. Thompson, Ross L. Levine, Ari Melnick, Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell. ,vol. 18, pp. 553- 567 ,(2010) , 10.1016/J.CCR.2010.11.015
Lenny Dang, David W. White, Stefan Gross, Bryson D. Bennett, Mark A. Bittinger, Edward M. Driggers, Valeria R. Fantin, Hyun Gyung Jang, Shengfang Jin, Marie C. Keenan, Kevin M. Marks, Robert M. Prins, Patrick S. Ward, Katharine E. Yen, Linda M. Liau, Joshua D. Rabinowitz, Lewis C. Cantley, Craig B. Thompson, Matthew G. Vander Heiden, Shinsan M. Su, Cancer-associated IDH1 mutations produce 2-hydroxyglutarate Nature. ,vol. 462, pp. 739- 744 ,(2009) , 10.1038/NATURE08617
Darrell R. Borger, Kenneth K. Tanabe, Kenneth C. Fan, Hector U. Lopez, Valeria R. Fantin, Kimberly S. Straley, David P. Schenkein, Aram F. Hezel, Marek Ancukiewicz, Hannah M. Liebman, Eunice L. Kwak, Jeffrey W. Clark, David P. Ryan, Vikram Deshpande, Dora Dias‐Santagata, Leif W. Ellisen, Andrew X. Zhu, A. John Iafrate, Frequent Mutation of Isocitrate Dehydrogenase (IDH)1 and IDH2 in Cholangiocarcinoma Identified Through Broad-Based Tumor Genotyping Oncologist. ,vol. 17, pp. 72- 79 ,(2012) , 10.1634/THEONCOLOGIST.2011-0386