Pharmacovigilance of antimalarial treatment in Africa: is it possible?

摘要: Pharmacovigilance, defined as "the science and activities relating to the detection, assessment, understanding prevention of adverse effects or any other possible drug related problem", is increasingly being recognized in Africa. Many African countries have simultaneously adopted artemisinin derivative based combination therapy (ACT) first-line treatment for uncomplicated malaria, offering an opportunity assess safety these drugs when used widely. While ACTs appear be safe well-tolerated, there little experience with medicines Africa, outside clinical trials. Pharmacovigilance treatments Africa essential. Malaria transmission intensity high antimalarial are frequently. Presumptive fever antimalarials common, often absence a confirmed diagnosis, using obtained without prescription. Informal use may increase risk incorrect dosing, inappropriate treatment, interactions, which impact negatively on safety. Furthermore, administration patients concomitant illness, including HIV/AIDs, tuberculosis malnutrition, concern. encouraged establish pharmacovigilance systems rolled out. However, difficult, even well-developed health care system. The rationale discussed here, outlining practical challenges proposing approaches that could