Peptide cotransmitter release from motorneuron B16 in aplysia californica: costorage, corelease, and functional implications.

摘要: Many neurons contain multiple peptide cotransmitters in addition to their classical transmitters. We are using the accessory radula closer neuromuscular system of Aplysia, which participates feeding these animals, define possible consequences modulators converging on single targets. How released onto targets is critical importance understanding outcomes modulatory actions and physiological role. Here we provide direct evidence that partially antagonistic families peptides, myomodulins buccalins, synthesized by motorneuron B16 costored coreleased fixed ratios. show this release calcium-dependent independent muscle contraction. Furthermore, initiated at low end range firing frequency it increases with increasing frequency. The coordination normal operating a neuron may be general phenomenon suggests exhibit similar types regulation plasticity as have been observed for Stimulation paradigms increase contraction amplitude or also from motor B16. net effect would relaxation rate therefore allow more frequent and/or larger contractions occur without increased resistance antagonist muscles. result modulation could maximize efficiency feeding.