Multimodal imaging of pancreatic beta cells in vivo by targeting transmembrane protein 27 (TMEM27)
作者： D. Vats , H. Wang , D. Esterhazy , K. Dikaiou , C. Danzer
DOI: 10.1007/S00125-012-2605-2
关键词:
摘要: Aims/hypothesis Non-invasive diagnostic tools specific for pancreatic beta cells will have a profound impact on our understanding of the pathophysiology metabolic diseases such as diabetes. The objective this study was to use molecular imaging probes specifically targeting human samples and animal models using state-of-the-art modalities (fluorescence PET) with preclinical clinical perspective.
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Ulf Ahlgren, Martin Gotthardt, Approaches for Imaging Islets: Recent Advances and Future Prospects Advances in Experimental Medicine and Biology. ,vol. 654, pp. 39- 57 ,(2010) , 10.1007/978-90-481-3271-3_3
Mira M. Sachdeva, Doris A. Stoffers, Minireview: Meeting the Demand for Insulin: Molecular Mechanisms of Adaptive Postnatal ß-Cell Mass Expansion Molecular Endocrinology. ,vol. 23, pp. 747- 758 ,(2009) , 10.1210/ME.2008-0400
D. Holmberg, U. Ahlgren, Imaging the pancreas: from ex vivo to non-invasive technology Diabetologia. ,vol. 51, pp. 2148- 2154 ,(2008) , 10.1007/S00125-008-1140-7
Melissa K Lingohr, Roland Buettner, Christopher J Rhodes, Pancreatic β-cell growth and survival – a role in obesity-linked type 2 diabetes? Trends in Molecular Medicine. ,vol. 8, pp. 375- 384 ,(2002) , 10.1016/S1471-4914(02)02377-8
David A. Mankoff, Janet F. Eary, Jeanne M. Link, Mark Muzi, Joseph G. Rajendran, Alexander M. Spence, Kenneth A. Krohn, Tumor-Specific Positron Emission Tomography Imaging in Patients: [18F] Fluorodeoxyglucose and Beyond Clinical Cancer Research. ,vol. 13, pp. 3460- 3469 ,(2007) , 10.1158/1078-0432.CCR-07-0074
Daria Esterházy, Ina Stützer, Haiyan Wang, Markus P. Rechsteiner, Jeremy Beauchamp, Heinz Döbeli, Hans Hilpert, Hugues Matile, Michael Prummer, Alexander Schmidt, Nora Lieske, Bernhard Boehm, Lorella Marselli, Domenico Bosco, Julie Kerr-Conte, Ruedi Aebersold, Giatgen Andreia Spinas, Holger Moch, Cristiano Migliorini, Markus Stoffel, Bace2 is a β cell-enriched protease that regulates pancreatic β cell function and mass. Cell Metabolism. ,vol. 14, pp. 365- 377 ,(2011) , 10.1016/J.CMET.2011.06.018
S. Schneider, Efforts to develop methods for in vivo evaluation of the native β-cell mass Diabetes, Obesity and Metabolism. ,vol. 10, pp. 109- 118 ,(2008) , 10.1111/J.1463-1326.2008.00944.X
Hong Zhang, Jun Wada, Kazuyuki Hida, Yoshinori Tsuchiyama, Keita Hiragushi, Kenichi Shikata, Haiyan Wang, Sun Lin, Yashpal S. Kanwar, Hirofumi Makino, Collectrin, a Collecting Duct-specific Transmembrane Glycoprotein, Is a Novel Homolog of ACE2 and Is Developmentally Regulated in Embryonic Kidneys Journal of Biological Chemistry. ,vol. 276, pp. 17132- 17139 ,(2001) , 10.1074/JBC.M006723200
K. J. Chang-Chen, R. Mullur, E. Bernal-Mizrachi, β-cell failure as a complication of diabetes Reviews in Endocrine & Metabolic Disorders. ,vol. 9, pp. 329- 343 ,(2008) , 10.1007/S11154-008-9101-5
Frederic Leblond, Scott C. Davis, Pablo A. Valdés, Brian W. Pogue, Pre-clinical whole-body fluorescence imaging: Review of instruments, methods and applications Journal of Photochemistry and Photobiology B-biology. ,vol. 98, pp. 77- 94 ,(2010) , 10.1016/J.JPHOTOBIOL.2009.11.007