Can multiparametric magnetic resonance imaging predict upgrading of transrectal ultrasound biopsy results at more definitive histology

摘要: Abstract Objective To determine whether multiparametric magnetic resonance imaging (mp-MRI) has a role in reducing the uncertainty risk stratification by transrectal ultrasound (TRUS) biopsy, using histology at transperineal template-guided prostate mapping (TPM) biopsy as reference test. Materials and methods Overall, 194 patients underwent TRUS who were followed up less than 18 months means of (a) mp-MRI with pelvic phased array T2-weighted, diffusion-weighted dynamic contrast-enhanced sequences (b) TPM biopsy. Of those patients, low on was defined 4 different ways—(a) definition 1: Gleason 3+3 (any cancer core length) (n = 137), 2: maximum length (MCCL) Results Median prostate-specific antigen level 7 ng/ml (range: 0.9–29), median time between 120 days 41–480), 60 1–420). A 48 cores 20–118) taken score upgraded 62 137 (45%) The negative predictive values 1 to 2 for predicting that remained (according each definition) 75%, 100%, 83%, 100% definitions 1, 2, 3, 4, respectively. An 5 had positive upgrade or upsize 59%, 67%, 69% Conclusion presence an lesion men low-risk confers, most high likelihood higher-risk disease will be present (either pattern significant burden). Conversely, if is not seen mp-MRI, attribution grade burden much more likely correct. Mp-MRI might therefore used triage resampling biopsies before entering active surveillance.