Population-based case-control investigation of risk factors for leptospirosis during an urban epidemic.

摘要: Between March and October 2000, 157 suspected cases of leptospirosis hospitalized with complications Weil's syndrome a mortality 8% were identified in Salvador, Brazil. We conducted population-based case-control study to identify risk factors for acquisition neighborhoods high endemicity during the rainy season-associated urban epidemic. Sixty-six (65%) 101 laboratory-confirmed 125 age sex-matched healthy neighborhood controls interviewed. Residence proximity an open sewer (matched odds ratio [OR] = 5.15, 95% confidence interval [CI] 1.80-14.74), peri-domiciliary sighting rats (OR 4.49, CI 1.57-12.83), groups five or more 3.90, 1.35-11.27), workplace exposure contaminated environmental sources 3.71, 1.35-10.17) found be independent acquiring disease. Some these are amenable focused interventions, which include provision closed drainage systems sewage reduction rodent populations peri-domicilary environment. Environmental control transmission may help greatly reduce incidence severe leptospirosis.