Opsoclonus-myoclonus syndrome associated with a nasopharyngeal tumor in an adult: a case report

摘要: Opsoclonus-myoclonus syndrome is a rare autoimmune usually seen in children and very rarely adults. It typically presents with triad of opsoclonus, myoclonus ataxia, most often associated tumor or after an infection vaccination. Around half all adult cases are paraneoplastic origin, isolated case reports include associations lung, breast ovarian cancers. To the best our knowledge, this first-ever reported opsoclonus-myoclonus occurring association nasopharyngeal carcinoma. A 50-year-old British Caucasian woman presented left-sided otalgia subjective hearing loss. Over coming weeks she developed subacute confusion dizziness, leading to recurrent falls. Her clinical examination revealed signs cerebellar dysfunction. Subsequent magnetic resonance imaging carcinoma, which was confirmed on biopsy. tapering dose steroids five-day course intravenous immunoglobulins, followed by combination chemo-radiotherapy for led significant improvement. At six months follow-up had no focal neurological deficit, apart from inability tandem walk. We believe that typical features, presence response treatment support aetiology. show carcinoma can be onset syndrome. Both neurologists otorhinolaryngologists must aware such presentation. Prognosis depends early adequate management tumor, therefore prompt identification underlying essential.