Non-adherence to anti-hypertensive medication in low- and middle-income countries: A systematic review and meta-analysis of 92443 subjects

摘要: Hypertension is a rising global burden, and low- middle-income countries account for 80% of deaths due to complications hypertension. can be controlled by adhering anti-hypertensive medication. However, non-adherence an increasing challenge. This review aims systematically evaluate medication among adults in explore factors affecting We performed systematic search studies published between 1 January 2000 31 August 2015. A selection process was data extraction with combination Medical Subject Headings terms: 'hypertension' 'adherence'. Further criteria were: language ('english'), species ('humans'), countries. total 22 met the inclusion criteria. The pooled percentage when using eight-item Morisky Medication Adherence Scale (MMAS) 63.35% (confidence interval (CI): 38.78-87.91) 25.45% (CI:17.23-33.76) 80 90% cut-off scales. were classified into five dimensions adherence defined World Health Organization, majority reported from dimension 'social economic factors'. demonstrated considerable variation depending on methods used estimate non-adherence. results showed high MMAS scale low scales used. fell within Organization