Retinal Vessel Tortuosity and Its Relation to Traditional and Novel Vascular Risk Markers in Persons with Diabetes

摘要: ABSTRACTPurpose/Aim: To investigate the association between retinal vascular tortuosity and traditional- vascular-related risk factors in persons with diabetes.Methods: We recruited 224 diabetic patients. Retinal was measured from fundus photographs. Association of following assessed after adjusting for significant co-factors: diabetes duration, HbA1c, systolic blood pressure (SBP), cholesterol body mass index (BMI), flicker-light induced vasodilatation, markers endothelial function inflammation (skin microvacular responses to acetylcholine iontophoresis, soluble e-selectin, inter-cellular adhesion molecule-1, cell endothelin-1, total nitrite, C-reactive protein).Results: Adjusting age gender, longer duration associated more tortuous arterioles (mean difference arteriolar 5.85 × 10−5, 95% Confidence Interval 1.44–10.3 × 10−5; p = 0.016; ≤10 versus >10...