The anionic permeability of the inhibitory postsynaptic membrane of hippocampal pyramidal cells

摘要: The anion permeability and current sensitivity of inhibitory postsynaptic potentials (i.p.s.ps) CA1 hippocampal pyramidal cells have been studied with intracellular recording techniques. Passage depolarizing through the microelectrode increased size i.p.s.ps while hyperpolarizing decreased eventually reversed i.p.s.ps. early portion i.p.s.p. was most sensitive to current. results obtained from injection anions into indicated that a sharp dichotomy existed: either permeable as shown by shift in i.p.s.p., or impermeable, there being consequence include Br$^{-}$, NO$_{2}^{-}$, NO$_{3}^{-}$, SCN$^{-}$, OCN$^{-}$, ClO$_{3}^{-}$ HCO$_{2}^{-}$, impermeable included citrate, glutamate, sulphate, methylsulphate, bromate, chromate, acetate fluoride. These are identical those ion motoneurons. Diffusion supported injection; namely, between permeant impermeant anions. However, acetate, lesser extent bromate were exceptions, since these led an abolition reduction yet studies clearly impermeant. Possible explanations for this paradox given following paper. present findings suggest membrane is similar reported spinal