Dengue NS1 antigen as a marker of severe clinical disease.

作者: Shiran Ajith Paranavitane , Laksiri Gomes , Achala Kamaladasa , Thiruni N Adikari , Nilanka Wickramasinghe

DOI: 10.1186/S12879-014-0570-8

关键词:

摘要: Early detection of complications significantly reduces dengue associated mortality and morbidity. We set out to determine if the NS1 rapid antigen test could be used as a point care predict severe disease. 186 adult patients with confirmed were enrolled during day 3-8 illness. Clinical laboratory parameters recorded course illness levels determined using both Panbio early ELISA (Panbio, Australia) kit (SD Bioline, South Korea). 59.1% presented hospital on 5-6 when positivity was (p = 0.008) (odds ratio 3.0, 95% CI 1.39 6.47) higher 0.03) in those who went develop shock. Serum < 0.0001) inversely correlated total white cell counts lymphocyte counts. The bedside showed comparable sensitivity (97.4%) specificity (93.7%) our setting cohort. is risk developing especially positive beyond 5 cohort, while further validation studies are required, can therefore potentially warning sign dengue.

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