OV6 + cancer stem cells drive esophageal squamous cell carcinoma progression through ATG7-dependent β-catenin stabilization
作者： Chao Wang , Fei-hu Yan , Jia-jun Zhang , Hai Huang , Qin-shu Cui
DOI: 10.1016/J.CANLET.2017.01.026
关键词:
摘要: Cancer stem cells (CSCs) represent a subpopulation of tumor that exhibit capacities for initiation and progression. Identifying CSCs their related pathways is necessary the development new therapeutic targets against tumors. However, molecular mechanism in esophageal squamous cell carcinoma (ESCC) remains elusive. This study demonstrated OV6 expression was closely associated with ESCC patients' clinical outcome prognosis. OV6+ possessed stronger stem-like properties, including self-renewal, cell-associated gene expression, tumorigenicity, chemo-resistance, invasion, metastasis. Autophagy maintained properties by stabilizing ATG7-dependent β-catenin. Furthermore, significantly positive correlation between ATG7 detected human biopsies, this could be used to predict Taken together, our findings provide novel potential CSC marker ESCC. cancer can promote progression through β-catenin stabilization. may serve as prognostic biomarker target patients.
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sci-hub.se 参考文章(35)
Lianggang Zhu, Hailei Du, Minmin Shi, Zhongyuan Chen, Junbiao Hang, ATG7 deficiency promote apoptotic death induced by Cisplatin in human esophageal squamous cell carcinoma cells Bulletin Du Cancer. ,vol. 100, pp. 15- 21 ,(2013) , 10.1684/BDC.2013.1749
Kozo Noguchi, Hidetoshi Eguchi, Masamitsu Konno, Koichi Kawamoto, Naohiro Nishida, Jun Koseki, Hiroshi Wada, Shigeru Marubashi, Hiroaki Nagano, Yuichiro Doki, Masaki Mori, Hideshi Ishii, Susceptibility of pancreatic cancer stem cells to reprogramming. Cancer Science. ,vol. 106, pp. 1182- 1187 ,(2015) , 10.1111/CAS.12734
Bruno Sainz, Sonia Alcala, Elena Garcia, Yolanda Sanchez-Ripoll, Maria M Azevedo, Michele Cioffi, Marianthi Tatari, Irene Miranda-Lorenzo, Manuel Hidalgo, Gonzalo Gomez-Lopez, Marta Cañamero, Mert Erkan, Jörg Kleeff, Susana García-Silva, Patricia Sancho, Patrick C Hermann, Christopher Heeschen, Microenvironmental hCAP-18/LL-37 promotes pancreatic ductal adenocarcinoma by activating its cancer stem cell compartment Gut. ,vol. 64, pp. 1921- 1935 ,(2015) , 10.1136/GUTJNL-2014-308935
Wen Yang, He-Xin Yan, Lei Chen, Qiong Liu, Ya-Qin He, Le-Xing Yu, Shu-Hui Zhang, Dan-Dan Huang, Liang Tang, Xiao-Ni Kong, Chao Chen, Shu-Qin Liu, Meng-Chao Wu, Hong-Yang Wang, Wnt/β-Catenin Signaling Contributes to Activation of Normal and Tumorigenic Liver Progenitor Cells Cancer Research. ,vol. 68, pp. 4287- 4295 ,(2008) , 10.1158/0008-5472.CAN-07-6691
Tania Roskams, Rita De Vos, Peter Van Eyken, Hiroshi Myazaki, Boudewijn Van Damme, Valeer Desmet, Hepatic OV-6 expression in human liver disease and rat experiments: evidence for hepatic progenitor cells in man Journal of Hepatology. ,vol. 29, pp. 455- 463 ,(1998) , 10.1016/S0168-8278(98)80065-2
Ming-Feng Wei, Min-Wei Chen, Ke-Cheng Chen, Pei-Jen Lou, Susan Yun-Fan Lin, Shih-Chieh Hung, Michael Hsiao, Cheng-Jung Yao, Ming-Jium Shieh, Autophagy promotes resistance to photodynamic therapy-induced apoptosis selectively in colorectal cancer stem-like cells Autophagy. ,vol. 10, pp. 1179- 1192 ,(2014) , 10.4161/AUTO.28679
Vivian SW Li, Ser Sue Ng, Paul J Boersema, Teck Y Low, Wouter R Karthaus, Jan P Gerlach, Shabaz Mohammed, Albert JR Heck, Madelon M Maurice, Tokameh Mahmoudi, Hans Clevers, None, Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex Cell. ,vol. 149, pp. 1245- 1256 ,(2012) , 10.1016/J.CELL.2012.05.002
Jiang-Sha Zhao, Wen-Jie Li, Di Ge, Pei-Jing Zhang, Jing-Jing Li, Chun-Lai Lu, Xiao-Dan Ji, Dong-Xian Guan, Hong Gao, Li-Yan Xu, Eng-Ming Li, Harmik Soukiasian, H. Phillip Koeffler, Xiao-Fan Wang, Dong Xie, Tumor Initiating Cells in Esophageal Squamous Cell Carcinomas Express High Levels of CD44 PLoS ONE. ,vol. 6, pp. e21419- ,(2011) , 10.1371/JOURNAL.PONE.0021419
Tomoya Sudo, Takeshi Iwaya, Naohiro Nishida, Genta Sawada, Yusuke Takahashi, Masahisa Ishibashi, Kohei Shibata, Hiromasa Fujita, Kazuo Shirouzu, Masaki Mori, Koshi Mimori, Expression of Mesenchymal Markers Vimentin and Fibronectin: The Clinical Significance in Esophageal Squamous Cell Carcinoma Annals of Surgical Oncology. ,vol. 20, pp. 324- 335 ,(2013) , 10.1245/S10434-012-2418-Z
Leo Alexandre, Allan B. Clark, Hina Y. Bhutta, Sean Holt, Michael P.N. Lewis, Andrew R. Hart, Statin Use Is Associated With Reduced Risk of Histologic Subtypes of Esophageal Cancer: A Nested Case-Control Analysis Gastroenterology. ,vol. 146, pp. 661- 668 ,(2014) , 10.1053/J.GASTRO.2013.11.046