Controllable Preparation of Chiral Oxazoline-Cu(II) Catalyst as Nanoreactor for Highly Asymmetric Henry Reaction in Water

摘要: A biomimetic nanoreactor of catalyst Cu(II)–PNxOy was prepared by reversible addition-fragmentation chain transfer polymerization (RAFT) starting from chiral amino acid. Characterizations this disclosed a clear thermoresponsive behavior in water. The oxazoline Cu single-chain nanoparticles (SCNPs) could undergo self-folding water to form nanoreactors which were capable catalyze the asymmetric Henry reaction. Dramatical acceleration reaction rate “concentrator effect” and outstanding catalytic efficiency observed system. Almost quantitative conversion (96%) 4-nitrobenzaldehyde with high enantioselectivity (ee value, 95%) achieved using only 2.0 mol% newly developed within 18 h Remarkably, be easily recovered regulating local temperature reused for at least 6 times without significant decrease reactivity. Utilizing new catalyst, benzaldehyde compounds nitromethane perform efficiently pure any addition organic solvent. This protocol offers an efficient environmentally benign method exhibits potential industrial applications.