Different copy numbers of apparently identically deleted mitochondrial DNA in tissues from a patient with Kearns-Sayre syndrome detected by PCR.
作者： B. Obermaier-Kusser , J. Müller-Höcker , I. Nelson , P. Lestienne , Ch. Enter
DOI: 10.1016/0006-291X(90)91994-4
关键词:
摘要: An apparently identical deletion of 4.977 bp in length (position 8,483-13,459) was detectable the mitochondrial DNA from skeletal muscle, heart kidney, and liver a patient with Kearns-Sayre syndrome. The proportion deleted genome varied 60% for muscle to 15% below 5% liver. mtDNA heteroplasmy only after amplification by PCR. In histochemical immunocytochemical findings concerning cytochrome c oxidase were good correlation DNA.
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