10-year follow-up of subclinical cardiovascular disease and risk of coronary heart disease in the Cardiovascular Health Study.

摘要: Background The incidence of coronary heart disease (CHD) is very high among individuals 65 years or older. Methods We evaluated the relationships between measurements subclinical at baseline (1989-1990) and third-year follow-up examination (1992-1993) subsequent cardiovascular total mortality as June 2001. Approximately 61% participants without clinical had based on our previously described criteria from Cardiovascular Health Study. Results CHD was substantially increased for with compared those who no disease: 30.5 per 1000 person-years 16.3 white individuals, 31.2 12.5 black individuals. risk persisted over entire period. Incidence rates were higher men than women disease, but there little difference in Conclusions In multivariable models, remained a significant predictor both women; hazard ratios (95% confidence intervals) their relative risks 1.64 (1.30-2.06) 1.49 (1.21-1.84), respectively. presence hypertension, diabetes mellitus, elevated C-reactive protein. summary, prevalent older independently associated even 10-year period, increases hypertension mellitus.