Ethical Considerations in Pharmacogenomic Testing and Research in Pediatrics

摘要: It is critical to resolve ethical issues surrounding genome-based testing in children because of the growing availability pharmacogenomic (PGx) testing, establishment pediatric DNA research databases, and unforeseen future implications identifying genomic variability individual children. Ethical concerns related analysis, as well legislation protect children, will require frequent evaluation be important fully informing patients, families, clinicians, researchers about potential risks benefits PGx distinct from other forms genetic presents novel considerations this benefit–risk relationship. If it can done without loss benefit, risk reduction a moral imperative; thus, we learn more technology’s actual value must continually addressed. Because complexity interpreting results, even for experienced many raised pediatrics are relevant adult patients caregivers.