Influence of skin model on in vitro performance of drug-loaded soluble microneedle arrays

摘要: Abstract A plethora of studies have described the in vitro assessment dissolving microneedle (MN) arrays for enhanced transdermal drug delivery, utilising a wide variety model membranes as representation skin barrier. However, to date, no discussion has taken place with regard choice membrane and impact this may on evaluation MN performance. In study, we have, first time, critically assessed most common types permeation models – synthetic hydrophobic (Silescol ® 75 μm) neonatal porcine definable thickness (300–350 μm 700–750 μm) evaluating performance loaded poly (methyl vinyl ether co maleic acid) (PMVE/MA) arrays. It was found that had significant effect range small hydrophilic molecules released from MNs. For example, when Silescol used membrane, cumulative percentage methylene blue 24 h after application dissolvable MNs be only approximately 3.7% total into device. comparison, dermatomed full were model, 67.4% 47.5% device delivered across arrays, respectively. The rat vivo revealed extent MN-mediated percutaneous delivery achieved similar predicted investigations employing (300–350 μm) membrane. On basis these results, wider within community will necessary standardise experimental protocols comparison devices.