Effects of Atomoxetine in Individuals with Attention-Deficit/Hyperactivity Disorder and Low-Functioning Autism Spectrum Disorder.
作者： Ayse Kilincaslan , Tuba Duzman Mutluer , Basak Pasabeyoglu , Mustafa Deniz Tutkunkardas , Nahit Motavalli Mukaddes
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摘要: Abstract Objectives: This naturalistic, retrospective study investigated the effects of atomoxetine (ATX) on attention-deficit/hyperactivity disorder (ADHD) symptoms and autistic features in children with autism spectrum disorders (ASDs) intellectual disability (ID). Methods: Participants (n = 37, age range 6–17 years, mean: 10.16 ± 3.60) were assessed at baseline, 4th 12th weeks using Clinical Global Impressions (CGI) scales, DSM-IV-based ADHD-rating scale (ADHD-RS), amended Turkish version Aberrant Behavior Checklist (ABC). The primary outcome measure was a treatment response defined by CGI-improvement score 1 or 2 together decrease least 25% parent-rated ADHD-RS total end week. Results: Five patients (13.5%) stopped medication 4 due to ineffectivity (2) intolerable side (increased motor activity talkativeness [n = 1], irritability [n = 2], temper outbursts increased blood pressure [n = 1]). Sixteen patien...
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