Dietary Protein, Aryl Hydrocarbon Hydroxylase and Chemical Carcinogenesis in Rats

摘要: The relationships of dietary protein to changes in hepatic aryl hydrocarbon hydroxylase activity and 7,12 dimethylbenz(a)anthracene ( DMBA ) carcinogenesis were studied female Sprague-Dawley rats. Iso- energetic casein based purified diets containing 7.5, 15, or 45% equivalent fed for 4 weeks, at which time rats killed enzyme assays. Aryl hydroxylase, an system metab olizes polycyclic aromatic hydrocarbons such as DMBA, showed increased increased. role the initiation phase was examined weeks whereupon each rat received 2.0 mg DMBA/100 g body weight a single oral dose. Thereafter all ad libitum 15% diet 25 additional weeks. percentage with tumors number per lower intake prior administration. influence on promotion by feeding administration assigned three experimental With this regimen, concentration had no effect tumor incidence latency during phase. Our evidence supports hypothesis that creasing may decrease potential car cinogenic metabolites reaching mammary gland stimulating metabolism DMBA. J. Nutr. 109: 55-62, 1979.