Tri-nasal triamcinolone acetonide nasal spray 200 and 400 μg qd versus placebo and nasacort triamcinolone acetonide nasal aerosol 440 μg qd in patients suffering from seasonal allergic rhinitis during the grass season

摘要: Tri-Nasal Nasal Spray is an investigational solution of triamcinolone acetonide (TAA) currently being evaluated as a treatment for allergic rhinitis. The safety and efficacy 200 400 micrograms once daily doses Spray, active control (440 Nasacort aerosol), placebo were compared over 2-week period in double-blind (the was not blinded), parallel design trial. A total 377 adult patients 13 centers enrolled during the grass pollen season. primary variable weekly average SSI (Symptom Severity Index), sum nasal congestion, rhinorrhea, sneezing severity scores from patient diary. 355 completed study. All treatments significantly more effective than relieving symptoms at each week. had rapid onset action, demonstrating significant improvement versus by second day treatment. Results individual other secondary measures paralleled those variables. comparable safety, treating nonocular seasonal