Influence of dietary medium-chain triglycerides on the development of N-methylnitrosourea-induced rat mammary tumors.

摘要: The mammary tumor-promoting effects of a high-fat (HF) diet (23%, w/w) containing 3:1 mixture medium-chain triglycerides (MCT) and corn oil were compared with those low-fat (LF) (5%) HF: w/w). It was found that the ingestion MCT in HF resulted no detectable animals initiated potent carcinogen N-nitrosomethylurea. Total palpable tumor incidence 60% HF:corn plus group, 66% LF:corn 87% group (p less than 0.03 p 0.06, respectively). However, when adenocarcinomas only counted, differences between groups not statistically significant, HF:MCT (57%) versus (77%), 0.08. Mean time to first (days) 122 +/- 40 (S.D.) MCT, 117 36 groups, 86 23 group. cumulative curves similar for 0.9); however, both significantly different from 0.0099). No multiplicity, size, or body weight gain any treatment groups. Assay serum total cholesterol showed consumption 23% depressed (but triglyceride) levels LF:5% oil- HF:MCT-containing diets. Analysis fatty acid profiles indicated fed exhibited twice amount linoleic (C18:2) as did either 5% MCT. Differences other acids much lesser magnitude. These results indicate effect can be diminished by substituting saturated more common longer-unsaturated-chain triglycerides. In addition, they suggest an association promotion cancer elevated lipids.