Hypotonous maculopathy after trabeculectomy with subconjunctival 5-fluorouracil

摘要: Long-term success in trabeculectomy has been enhanced recent years by postoperative subconjunctival 5-fluorouracil injections and intraoperative mitomycin C applications. During 1990 1991, after with a small scleral flap (2 × 3 mm) augmented antimetabolite therapy, hypotonous maculopathy developed eight eyes of six patients. The was characterized loss visual acuity, retinal striae, choroidal folds without evidence vascular leakage. average acuity four Snellen lines. Visual did not return to preoperative levels even when the hypotony could be reversed. Reversing various strategies aimed at stimulating scarring relatively ineffective. that same period, an additional seven patients had prolonged but development maculopathy. Features common who included age (mean age, 46 years; range, 32 60 years) myopia (mean, -7.5 diopters; -0.75 -11.75 diopters). no were older 73 63 82 closer emmetropia -1.11 +1.50 -9.00 means ages refractive errors statistically significantly different two groups (P = .007 .04, respectively). Trabeculectomy adjunctive antifibrosis therapy should used caution young myopic