Molecular Pathology of Oxidative Damage Induced by the Myeloperoxidase System of Activated Phagocytes

摘要: Oxidant generation is implicated as a major contributor to aging and the degenerative diseases of process (1,2). However, physiologically relevant mechanisms for oxidative damage have not yet been identified. A potential pathway involves activated phagocytic white blood which employ membrane-associated NADPH oxidase generate superoxide (3,4). Superoxide spontaneously or enzymatically dismutates form hydrogen peroxide. In vitro studies suggest that peroxide alone relatively unreactive oxidant. amplified by myeloperoxidase, secreted heme protein The enzyme represents an attractive candidate monitoring phagocyte-mediated because it generates several distinct oxidants covalently modify cellular targets.