A Model of Blood Pressure, Heart Rate, and Vaso-Vagal Responses Produced by Vestibulo-Sympathetic Activation.

摘要: Blood Pressure (BP), comprised of recurrent systoles and diastoles, is controlled by central mechanisms to maintain blood flow. Periodic behavior BP was modeled study how peak amplitudes frequencies the are modulated vestibular activation. The model implemented as a relaxation oscillator, driven signal related Desired BP. Relaxation oscillations were maintained second order system comprising two integrators threshold element in feedback loop. output generated nonlinear function derivative first state variable, which summation an input BP, from states, into one loops. This structured best simulate shapes relationship between Heart Rate (HR) well amplitude modulations Pulse Pressure. Increases loops produced lower HR, but large pulse pressures orthostasis, without generating VasoVagal Response (VVR). considerably smaller anesthetized rats than during simulations, simulated lowered including saturation Stochastic changes compensatory Baroreflex Sensitivity. Sudden decreases elicited non-compensatory VVRs with pressures, consistent experimental data. suggests that Vestibular Sympathetic Reflex (VSR) modulates HR oscillating manipulating parameters baroreflex signals oscillations. It also shows VVR when triggers marked reduction