Iron, neuroinflammation, and Alzheimer's disease.

摘要: The present article reviews the roles and interactions of iron neuroinflammation in Alzheimer's disease. It highlights importance neuroinflammatory changes glial scar after neuronal injury, promoting accumulation, iron-dependent oxidative damage. Elevation disease not only affects amyloid precursor protein processing mitochondrial function but also induces aggregation Abeta peptide abnormalities signal transduction processes associated with Collective evidence suggests that although alterations homeostasis may be primary triggering event starts pathological cascade disease, it is an important factor involved progression this