Fracture Risk Reduction with Alendronate in Women with Osteoporosis: The Fracture Intervention Trial

摘要: We examined the effect of alendronate treatment for 3-4 yr on risk new fracture among 3658 women with osteoporosis enrolled in Fracture Intervention Trial. This cohort included existing vertebral and those as defined by T score less than -2.5 at femoral neck but without fracture. All analyses were prespecified data analysis plan. The magnitudes reduction incidence similar both groups. two groups were, therefore, pooled to obtain a more precise estimate relative (relative risk, 95% confidence interval): hip (0.47, 0.26-0.79), radiographic (0.52, 0.42-0.66), clinical (0.55, 0.36-0.82), all fractures (0.70, 0.59-0.82). Reductions statistically significant 12 months into trial. conclude that reductions during are consistent such bone mineral density osteoporotic range. Furthermore, is evident early course treatment. provides antifracture efficacy prior reports.