Modular organ microphysiological system with microbiome

摘要: Fluidic multiwell bioreactors are provided as a microphysiological platform for in vitro investigation of multi-organ crosstalks with microbiome an extended period time at least weeks and months. The has one or more improvements over existing bioreactors, including on-board pumping pneumatically driven fluid flow, redesigned spillway self-leveling from source to sink, non-contact built-in level sensing device, precise control on flow profile partitioning, facile reconfigurations such daisy chaining multilayer stacking. supports the culture multiple organs together microphysiological, interacted systems, suitable wide range biomedical applications systemic toxicity studies physiology-based pharmacokinetic pharmacodynamic predictions. A process fabricate is also provided.